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This fatigue can be caused by the cytokinin storm, which leads to inflammations and anorexia, followed by muscle loss, weakness, and fatigue

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While there might be a theoretical appeal to combining their distinct mechanisms, the potential for amplified side effects and drug interactions necessitates a cautious approach under strict medical supervision

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The mtDNA copy number was increased by exendin-4 and SRT172 and reduced by nicotinamide, compared with control (Fig